Treatment of acute HIV infection: diagnostic trajectory and research
Recent studies have demonstrated that when people are treated in the very early stages of an HIV infection (i.e., during the acute infection phase), the virus remains under control in some of these people, even after they stop treatment. This is called ‘post-treatment control’. This only occurs in a very small number of individuals and it is unclear which factors contribute to this post-treatment control. The H-TEAM investigates the effect of very early treatment on the immune system and the virus in the NOVA study.

Diagnostic trajectory & NOVA cohort study
The study focuses on people living with HIV in the acute infection phase. This phase comprises the first weeks after infection has taken place. Identifying an acute HIV infection (AHI) is of great importance, as recent studies have demonstrated that starting ART in this phase improves the prognosis of people living with HIV in the long run. In addition, there is an increased risk of transmitting the virus during this first period. Identifying and treating an AHI is therefore beneficial for the individual and significantly reduces the risk of transmitting the virus to others.
This study comprises three components:
1. AHI diagnostic & referral trajectory
2. AHI diagnostic & linkage-to-care trajectory at the STI clinic Amsterdam
3. NOVA cohort study
Scroll down for more information on these components.
Team
-
Annelies Verbon
Member
ErasmusMC -
Casper Rokx
Member
ErasmusMC -
Godelieve de Bree
Project Leader
Amsterdam UMC
AIGHD -
Jan Prins
Member
Amsterdam UMC -
Peter Reiss
Member
Amsterdam UMC
AIGHD -
Pien van Paassen
Member
AIGHD